L.S.D. is an Indica-dominant strain, named after the potent psychedelic drug. It is a cross between a Mazar and Skunk #1 by Barney’s Farm. The strain starts with an upbeat sense of happiness that can cloud the mind and leave some users completely confused and "mentally stuck." Some users claim to feel more creative or social after using L.S.D. in spite of the strong cerebral stimulation. This degree of mental stimulation is quite rare for an Indica. Not surprisingly, L.S.D. also has typical Indica-based body effects. Users often notice the powerful body numbing 1 to 2 hours after ingestion, once most of the cerebral effects wear off. For most, this strain can be used any time of day to ease mild to moderate chronic aches and pains. L.S.D. is often prescribed to help deal with stress, anxiety, or depression. Patients also use the strain to treat insomnia, and a few choose it to help combat migraines. 

Information from wikileaf.com and allbud.com